ISSN 1662-4009 (online)

ey0016.7-11 | Clinical Guidance | ESPEYB16

7.11. Gonadal function and pubertal development in patients with Silver-Russell syndrome

WJ Goedegebuure , CCJ Smeets , JS Renes , YB de Rijke , ACS Hokken-Koelega

To read the full abstract: Hum Reprod. 2018 Nov 1;33(11):2122–2130This longitudinal study of 31 patients (14 males) with Silver-Russell syndrome (SRS) and 123 non-SRS small-for-gestational-age (SGA) patients (65 males) shows that Sertoli cell dysfunction is more common in SRS males, with 11p15 loss of methylation (LOM), but gonadal function seems to be unaffected in SRS females....